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Evi Kostenis Selected Research

ramatroban

2/2007Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.
4/2006On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.
8/2005Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.
2/2005Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.

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Evi Kostenis Research Topics

Disease

10Asthma (Bronchial Asthma)
04/2016 - 02/2005
7Inflammation (Inflammations)
01/2022 - 01/2006
5Type 2 Diabetes Mellitus (MODY)
05/2013 - 10/2010
3Obesity
01/2022 - 11/2008
3Melanoma (Melanoma, Malignant)
10/2018 - 12/2015
3Allergic Rhinitis
11/2010 - 02/2005
2Pneumonia (Pneumonitis)
05/2022 - 01/2017
2Insulin Resistance
01/2022 - 01/2015
2Pain (Aches)
01/2022 - 01/2020
2Wounds and Injuries (Trauma)
01/2020 - 11/2019
2Neoplasms (Cancer)
01/2019 - 12/2016
2Uveal melanoma
01/2019 - 01/2019
2Metabolic Diseases (Metabolic Disease)
06/2015 - 11/2008
2Atopic Dermatitis (Atopic Eczema)
01/2012 - 11/2010
2Eosinophilia
02/2007 - 11/2006
2Hyperplasia
02/2007 - 11/2006
1Systemic Scleroderma (Systemic Sclerosis)
05/2022
1Fibrosis (Cirrhosis)
05/2022
1Anaphylaxis (Anaphylactic Shock)
01/2022
1Crohn Disease (Crohn's Disease)
01/2022
1Body Weight (Weight, Body)
01/2021
1Thinness
01/2021
1Glucose Intolerance
01/2021
1Hyperglycemia
10/2020
1Opioid-Related Disorders (Opiate Addiction)
01/2020
1Psychotic Disorders (Schizoaffective Disorder)
11/2019
1Schizophrenia (Dementia Praecox)
11/2019
1Myositis Ossificans (Fibrodysplasia Ossificans Progressiva)
10/2019
1Nervous System Diseases (Neurological Disorders)
11/2018
1Lung Diseases (Lung Disease)
09/2017
1Infections
01/2017
1Carcinoma (Carcinomatosis)
01/2017
1Norrie disease
10/2016
1Familial Exudative Vitreoretinopathies
10/2016
1Demyelinating Diseases (Demyelinating Disease)
01/2016
1Multiple Sclerosis
01/2016
1Polymicrogyria
01/2016
1Fatty Liver
01/2015
1Contact Dermatitis (Eczema, Contact)
08/2014
1Weight Loss (Weight Reduction)
04/2011
1Chronic Obstructive Pulmonary Disease (COPD)
11/2010

Drug/Important Bio-Agent (IBA)

7Nonesterified Fatty Acids (NEFA)IBA
01/2022 - 10/2010
6Glucose (Dextrose)FDA LinkGeneric
01/2021 - 11/2008
5Proteins (Proteins, Gene)FDA Link
10/2019 - 12/2015
5ProstaglandinsIBA
11/2010 - 02/2005
4GTP-Binding Proteins (G-Protein)IBA
01/2019 - 08/2005
4Prostaglandins DIBA
02/2012 - 01/2006
4ramatrobanIBA
02/2007 - 02/2005
2Peptides (Polypeptides)IBA
05/2022 - 01/2020
2Opioid Peptides (Opioid Peptide)IBA
01/2022 - 01/2020
2Opioid Analgesics (Opioids)IBA
01/2022 - 01/2020
2Opioid Receptors (Opioid Receptor)IBA
01/2022 - 01/2020
2Fatty Acids (Saturated Fatty Acids)IBA
01/2021 - 06/2015
2Triglycerides (Triacylglycerol)IBA
01/2021 - 01/2015
2Chemokine ReceptorsIBA
01/2020 - 11/2019
2CytokinesIBA
01/2017 - 01/2016
2Conjugated Linoleic AcidsIBA
01/2015 - 04/2011
2prostaglandin D2 receptorIBA
02/2007 - 01/2006
1AntibodiesIBA
05/2022
1AutoantibodiesIBA
05/2022
1Angiotensin Receptors (Angiotensin II Receptor)IBA
05/2022
1Insulin (Novolin)FDA Link
01/2022
1NociceptinIBA
01/2022
1CC ChemokinesIBA
01/2022
1CCX282-BIBA
01/2022
1LeptinIBA
01/2021
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
01/2021
1Volatile Fatty AcidsIBA
10/2020
1Pharmaceutical PreparationsIBA
10/2020
1Serotonin (5 Hydroxytryptamine)IBA
11/2019
1Antipsychotic Agents (Antipsychotics)IBA
11/2019
1Glutamic Acid (Glutamate)FDA Link
11/2019
1activin AIBA
10/2019
1Pasteurella multocida toxinIBA
10/2019
1Oncogene Proteins (Oncogene Protein)IBA
01/2019
1Codon (Codons)IBA
01/2019
1LigandsIBA
11/2018
1Ion Channels (Ion Channel)IBA
11/2018
1Thrombin Receptors (Thrombin Receptor)IBA
10/2018
1heparanaseIBA
10/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2018
1Interleukin-13IBA
01/2017
1Interleukin-9 (Interleukin 9)IBA
01/2017
1neuromedin UIBA
01/2017
1Interleukin-5 (Interleukin 5)IBA
01/2017
1InterleukinsIBA
01/2017
1NeuropeptidesIBA
01/2017
1IntegrinsIBA
12/2016
1Phospholipids (Phosphatides)FDA LinkGeneric
12/2016
1Lysophosphatidylcholines (Lysophosphatidylcholine)IBA
12/2016
1Biomarkers (Surrogate Marker)IBA
12/2016
1Retinaldehyde (Retinal)IBA
10/2016
1Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
10/2016
1erythromycin propionate-N-acetylcysteinateIBA
01/2016
15,9,12-octadecatrienoic acidIBA
06/2015
1ChemokinesIBA
08/2014
1beta-Arrestin 1IBA
08/2014
1Biological ProductsIBA
02/2012
1Cell Surface ReceptorsIBA
04/2011

Therapy/Procedure

1Therapeutics
01/2017